The reference site for Perphenazine

Perphenazine is a typical antipsychotic drug. Chemically, it is classified as a piperazinyl phenothiazine. Originally marketed in the US as Trilafon, it has been in clinical use for decades.

WHAT IS PERPHENAZINE?

Perphenazine is used to treat serious mental disorders such as schizophrenia. It has also been used to treat severe nausea and vomiting.

Perphenazine is one of many drugs in the class called phenothiazine derivatives. Phenothiazines work by inhibiting the actions of the brain chemicals, dopamine and norepinephrine, which are overproduced in individuals with psychosis.

It is sold in the United States under the brand name Trilafon®, and is also available under various generic forms.

 

Brand Name(s): Trilafon; Etrafon (combination with amitriptyline)
CAS nº: 58-39-9
(per FEN a zeen)

 

Product Info

The sections below will provide you with more specific information and guidelines related to perphenazine and its correct use. Please read them carefully.

FDA Information

Perphenazine was approved by the Food and Drug Administration in 1957. A prescription is required for this medicine.

Please visit the official site of the FDA for further information.

Why is this medication prescribed?

Perphenazine is used to treat serious mental disorders such as schizophrenia. It has also been used to treat severe nausea and vomiting.

Perphenazine is one of many drugs in the class called phenothiazine derivatives. Phenothiazines work by inhibiting the actions of the brain chemicals, dopamine and norepinephrine, which are overproduced in individuals with psychosis.

Other uses for this medicine

Perphenazine has been sometimes used in low doses as a ‘normal’ or ‘minor’ tranquilizer in patients with a known history of addiction to drugs or alcohol in the past, a practice which is now strongly discouraged (better results have been seen by using an antidepressive drug, such as doxepin, for this indication).

Perphenazine also has sedating and anxiolytic properties making the drug particularly useful for the treatment of agitated psychotic patients and, in high doses (up to 100mg per day), for patients with life-threatening (febrile) catatonia, a state in which the patient is extremely agitated, but is not able to express him/herself. In this situation perphenazine may be used together with electroconvulsive therapy and correction of electrolytes/fluids in the body.

A valuable off-label indication is the short-time treatment of hyperemesis gravidarum, a state in which pregnant women experience violent nausea and emesis. This problem can become severe enough to endanger the life of the unborn. As perphenazine has not been shown to be teratogenic and works very well, it is sometimes given orally in the least possible dose.

Nevertheless, it is important that you talk to your doctor about the possible risks of using this drug for your particular condition.

Dosage and using this medicine

Perphenazine comes as an oral tablet and liquid concentrate. It is usually taken three times a day.

Take perphenazine exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each tablet dose with a full glass (8 ounces) of water, either with or without food.

Mix the concentrate with 4 ounces of water, juice, ginger ale, or a semisolid food such as apple sauce or pudding.

Do not mix the liquid with coffee, tea, cola, grape, or apple juice.

Do not let the liquid touch your skin or clothes.

Do not stop taking perphenazine without the approval of your doctor. It may be several weeks before you begin to feel better, and you may require continuous treatment for quite some time. Talk to your doctor before you stop taking this medication.

Additionally, please throw away any discolored liquid.

What special precautions should I follow?

BEFORE TAKING PERPHENAZINE:

Tell your doctor if you have a bone marrow disease, glaucoma, seizures, Parkinson’s disease, an enlarged prostate or difficulty urinating, liver disease, or kidney disease. You may not be able to take perphenazine, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

Also inform your doctor if you are taking any of the following drugs: antacids (take antacids at least 2 hours before or 2 hours after taking a dose of perphenazine. They will decrease the effectiveness of perphenazine); alcohol; over-the-counter cough, cold, or allergy medications; sleep aids; antidepressants; muscle relaxants; barbiturates; and seizure medications. All of these medications will increase the side of effects of perphenazine – especially drowsiness and dizziness. Additionally, blood pressure medications such as propranolol (Inderal®), methyldopa (Aldomet®), and clonidine (Catapres®) may cause dizziness and fainting if used with perphenazine. Combining perphenazine with anticoagulants such as warfarin (Coumadin®) can also decrease the effectiveness of these medications, and blood clotting could result. Perphenazine may increase the effectiveness of phenytoin (Dilantin®) and cause side effects. You may need smaller doses of phenytoin.

Drugs other than those listed here may also interact with perphenazine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

It is not known whether perphenazine will harm an unborn baby. Moreover, it is not known whether perphenazine passes into breast milk. Do not take perphenazine without first talking to your doctor if you are pregnant or breast-feeding a baby.

If you are over 60 years of age, you may be more likely to experience side effects from perphenazine so you may require a lower dosage.

Use cautiously when driving, operating machinery, or performing other hazardous activities. Perphenazine may cause dizziness or drowsiness, so try to avoid these activities.

Dizziness may be more likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall.

Alcohol use may increase drowsiness and dizziness while you are taking perphenazine.

Furthermore, avoid prolonged exposure to sunlight. Perphenazine may increase the sensitivity of your skin to sunlight. Use a sunscreen and wear protective clothing when sun exposure is unavoidable.

What should I do if I forget a dose?

If you take one dose of perphenazine a day, take the missed dose as soon as you remember, then go back to your regular schedule the next day. If you do not remember until the next day, then skip the dose you missed and take only your next regularly scheduled dose. It is strongly advised never take a double dose of this medication.

If you are taking perphenazine on a regular schedule several times a day, take the missed dose within 1 hour of its regular time. If more than 1 hour has passed, skip the missed dose and take only the next regularly scheduled dose. Please do not take a double dose of this medication.

If you are taking perphenazine as needed for nausea and vomiting, take the missed dose as soon as possible, then wait at least 4 hours before taking another dose.

What side effects can this medication cause?

If you experience any of the following serious side effects, stop taking perphenazine and seek emergency medical treatment:

an allergic reaction (such as difficulty breathing, closing of your throat, swelling of your lips, tongue, or face, or hives)
uncontrollable movements of the tongue, face, lips, arms, or legs
muscle spasms of the face or neck
severe restlessness or tremor
severe drowsiness or fainting
a rash

Other, less serious side effects may be more likely to occur. Continue to take perphenazine and talk to your doctor if you experience:

decreased sweating
dry mouth, stuffy nose
constipation
blurred vision
mild restlessness, drowsiness, or tremor
difficult urination or dark urine
decreased sex drive
dizziness
increased appetite
menstrual irregularities or swollen breasts

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Always keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Remember to throw away any medication that is outdated or no longer needed.If you have any questions, then please talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of an overdose, call your local poison control center on 1-800-222-1222. However, if the victim has collapsed or is not breathing,  then please call the local emergency services on 911.

Symptoms of overdose may include:

uncontrollable movements
agitation
seizures
severe dizziness or fainting
coma
very deep sleep
irregular heartbeats
high or low body temperature

Product Images

PICTURES OF PERPHENAZINE PRODUCTS

Below you will find images and specific information on the principal types of perphenazine that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: PERPHENAZINE
Strength(s): 2 MG
Imprint: GG 18
Manufacturer: SANDOZ

Name: PERPHENAZINE
Strength(s): 2 MG
Imprint: 4940 V
Manufacturer: VINTAGE PHARMACEUTICALS

Name: PERPHENAZINE
Strength(s): 4 MG
Imprint: GG 107
Manufacturer: SANDOZ

Name: PERPHENAZINE
Strength(s): 4 MG
Imprint: 4941 V
Manufacturer: VINTAGE PHARMACEUTICALS

Name: PERPHENAZINE
Strength(s): 8 MG
Imprint: 3669 8
Manufacturer: IVAX

Name: PERPHENAZINE
Strength(s): 8 MG
Imprint: GG 108
Manufacturer: SANDOZ

Name: PERPHENAZINE
Strength(s): 16 MG
Imprint: 3670 16
Manufacturer: IVAX

Name: PERPHENAZINE
Strength(s): 16 MG
Imprint: GG 109
Manufacturer: SANDOZ

Name: PERPHENAZINE
Strength(s): 16 MG
Imprint: 4943 V
Manufacturer: VINTAGE PHARMACEUTICALS

Name: TRILAFON®
Strength(s): 2 MG / 5 ML
Imprint: TRIFALON
Manufacturer: SHERING CORP.

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